Starting on EPKINLY

Discover a new kind of DLBCL treatment

EPKINLY is a treatment for people with certain types of diffuse large B-cell lymphoma (DLBCL) whose cancer has returned or didn't respond after 2 or more prior treatments. It's the first-and-only FDA-approved bispecific antibody given as a subcutaneous injection, which means it’s given under the skin.

Woman sitting inside.

How EPKINLY is given

EPKINLY is given by your healthcare provider as a subcutaneous injection (an injection given under the skin). You will be able to receive EPKINLY as soon as you and your healthcare provider are ready to begin treatment.

EPKINLY dosing schedule

ONCE
A WEEK

FOR 12 WEEKS

then

ONCE
EVERY
2 WEEKS

FOR 24 WEEKS

then

ONCE
EVERY
4 WEEKS

AFTER THAT

  • Your EPKINLY treatment schedule is divided into cycles that are usually 28 days (4 weeks) long
  • During the first 2 weeks of treatment, you will receive smaller doses than what you receive in week 3 and for the rest of your treatment. This is called a "step-up dosing schedule." This is designed to help reduce the risk and severity of cytokine release syndrome (CRS)
  • Due to the risk of CRS and neurologic problems, you should be hospitalized for 24 hours after receiving your first full dose of EPKINLY at week 3 (day 15 of cycle 1)

You will continue to receive EPKINLY as long as your doctor finds it is working for you and your side effects are manageable.

Things to know:

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What are some things to know about treatment with EPKINLY?

You may have side effects during or after your injection. EPKINLY can cause serious side effects including CRS, neurologic problems, infections, and low blood counts. Your healthcare provider will monitor you for symptoms of CRS and neurologic problems during treatment with EPKINLY, as well as other side effects, and treat you if needed. Your healthcare provider may temporarily or completely stop your treatment with EPKINLY if you develop CRS, neurologic problems, or any other side effects that are severe.

Before each dose of EPKINLY in your first 4 weeks of treatment, you will receive medicines to help reduce the risk of CRS. Your healthcare provider will decide if you need to receive medicine to help reduce the risk of CRS in later doses of EPKINLY.

Do not drive, operate heavy machinery, or do other dangerous activities if you develop dizziness, confusion, tremors, sleepiness, or any other symptoms that impair consciousness until your symptoms go away. These may be symptoms of CRS or neurologic problems.

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How long will I receive EPKINLY?

You will continue to receive EPKINLY as long as your doctor finds it is working for you and your side effects are manageable. Your healthcare provider may temporarily or completely stop your treatment with EPKINLY if you develop CRS, neurologic problems, or any other side effects that are severe.

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What if I can't make my dosing appointment?

You should contact your healthcare provider if you can't attend your regularly scheduled dosing appointment. They can walk you through what you may need to do if you miss a dose.

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Keep this card with you in the event a healthcare provider needs to quickly reference your important information.

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Keep track of how you are feeling and questions you have for your healthcare team in your EPKINLY Treatment Tracker.

A woman placing her hand on a patient's  shoulder.

Get support, helpful links, and resources to help you with your treatment.